Animal experiments suggest that the metabolism of vasopressin is primarily by liver and kidney. Incompatibilities are based on meeting any of the following criteria. In high concentrations, it raises blood pressure by inducing moderate vasoconstriction, and it has been shown to be more effective than epinephrine in asystolic cardiac arrest wenzel v, krismer ac, arntz hr, sitter h, stadlbauer kh, lindner kh january 2004. Vasopressin december 17 update the society of hospital. Its safe to use vasopressors through a good 20g peripheral iv for a period less than 48 hours from the same iv and as long as the requirements remain less than 20 mcg of norepinephrine or 30 mcg of epinephrine or 100mcg of phenylephrine or 0.
Critical care intravenous drug administration guide. Vasopressin is usually given as needed to help control your condition. Iv ysite infusion solution compatibility data infusion solution compatible. Prior to administration, have second practitioner independently check. Some products contain alcohol and propylene glycol. Use glass bottles and nonpvc polyvinyl chloride tubing to avoid adsorption of drug to delivery devices. Intravenous compatibility chart free html5 flip book. Ysite injection drug compatibility chart for critical.
Atenolol iv bolus under supervision of a doctor maximum rate 1mgminute dose. Vasopressin, also called antidiuretic hormone adh, arginine vasopressin avp or argipressin, is a hormone synthesized as a peptide prohormone in neurons in the hypothalamus, and is converted to avp. Patients receiving vasopressin petressin assessment. The lack of compatibility data on the coadministration of iv sildenafil with other drugs in critical care means a dedicated line is required for sildenafil. Vasopressin injection, usp is a sterile solution of synthetic vasopressin of the posterior pituitary gland for intramuscular im or subcutaneous use. Drugs administered to patients receiving pn should be given through a separate iv site or catheter lumen. Detailed listing of the iv drug compatibility and stability updates applied to the king guide to parenteral admixtures over the last 12 years. One study used the same concentrations of each medication as we report in this study with the same results but in a different vehicle and for 24 hours. It is substantially free from the oxytocic principle and is standardized to contain 20 usp unitsml. The following is the list of drugs found on the king guide to parenteral admixtures critical care admixtures wall chart.
For an additional discussion of dosage, consult the sections below. The prescriber is responsible for the verification of indications and dosages listed in the manufacturers package insert for the individual drugs, from which most information for this dosing guide is obtained. Thames valley ysite intravenous drugs compatibility chart. Pn solutions are diverse in their composition and compatibilities with drugs can never be guaranteed. This reference contains standard dilutions including iv admixture drug concentration, infusion volumes, and infusion rates. Essential coverage of 48 of the most common and complex iv drugs, including drip rate calculation charts, drug calculation formulae, and much more help you safely and efficiently administer iv drugs. Vasostrict is used to help reduce the buildup of fluid in the abdominal area, in emergency. The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Additive compatibility drugs in syringe compatibility. Safety and efficacy have not been established in patients younger than 18 years. Intravenous compatibility chart drug information for the. Indications, dose, contraindications, sideeffects, interactions, cautions, warnings and other safety information for vasopressin.
Iv doses should be expressed in milligrams not ampules, concentration or volume. It then travels down the axon of that cell, which terminates in the posterior pituitary, and is released from vesicles into the circulation in response to extracellular fluid hypertonicity. Known allergy or hypersensitivity to 8larginine vasopressin or chlorobutanol. When given intravenously, ddavp has been shown to cause a temporary increase. The majority of sources cited define compatibility by physical compatibility rather than chemical compatibility this table is a guide only. Vasopressin should be given intramuscularly at threeor fourhour intervals as needed. It is substantially free from the oxytocic principle and is standardized to contain 20 pressor unitsml. Ysite injection drug compatibility chart for critical care wards. This application provides the healthcare profession with a method of quickly checking the compatibility of any two of the following intravenous drugs at the ysite. Digital books looseleaf edition database licensing.
P31 compatibility of sildenafil citrate with noradrenaline. This project investigated physical compatibilities of intravenous medications. Intravenous iv preparation and infusion guidelines globalrph. Vasopressin is injected into a muscle or under the skin, or into a vein through an iv. Hypersensitivity or anaphylaxis to the active component or to any of the ingredients.
Full information can be obtained from your pharmacy department key references adrenaline 18 1 compatible reference 1 1 handbook of injectable drugs lawrence trissel available on. Pitressin vasopressin injection, usp synthetic is a sterile, aqueous solution of synthetic vasopressin 8arginine vasopressin of the posterior pituitary gland. Argipressin vasopressin newborn use only 2017 neonatal medicines formulary consensus group argipressin vasopressin page 2 of 6 this is a printed copy refer to the electronic system for most up to date version or glucose 5% 0. Adverse effects reported with iv vasopressin for the treatment of vasodilatory shock include hemorrhagic shock, decreased platelets, intractable bleeding, right heart failure, atrial fibrillation, bradycardia, myocardial ischemia, mesenteric ischemia, increased bilirubin levels, acute renal insufficiency, distal limb ischemia. Assess for presencehistory of diabetes insipidus, antidiuretic hormone deficiency. Full text monographs for most every injectable drug available are reported in the complete king guide to parenteral admixtures. Parenteral nutrition pn and drug compatibility the coinfusion of drugs and pn should be avoided. A handbook for nurses and health professionals has been a trusted resource for comprehensive drug coverage, unparalleled accuracy, and an intuitive quickaccess format. The 10 ml multiple dose vasopressin vial contains chlorobutanol and is therefore contraindicated in patients with a known hypersensitivity to chlorobutanol. Physical compatibility of pantoprazole with selected. Vasopressin is a polypeptide hormone that causes contraction of vascular and other smooth muscles and antidiuresis. The dosage should be proportionately reduced for children.
Patients receiving vasopressin petressin assessment prior to administration. Critical care admixtures wall chart list of iv drugs. Several studies have been conducted comparing vasopressin to octreotide. Investigations of physical compatibilities of commonly. Acetylcysteine adrenaline alfentanil aminophylline amiodarone aprotinin atracurium calcium chloride calcium gluconate ciprofloxacin cisatracurium clonidine compound sodium lactate. Only vasopressin and octreotide are available in the united states 7, 19.
The essential information you need to safely administer more than 400 intravenous drugs. Intravenous admixtures preparation and infusion guidelines. A healthcare provider will give you this injection. Also, epinephrine is much safer than norepinephrine. Sodium thiosulfate, vasopressin, and vecuronium bromide. Information in this booklet should be used as a guide only. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug. Vasopressin is contraindicated in patients with a known hypersensitivity to 8larginine vasopressin. Obtain complete health history including allergies, drug history and possible drug interactions. In addition to updating drug interactions, precautions, alerts, and patient teaching. Vasopressin is a primary drug used in the pulseless arrest algorithm. Vasopressin is predominantly metabolized and only about 6% of the dose is excreted unchanged in urine. Vasopressin is the generic name for a prescription drug also available under the brand name vasostrict. The ysite compatibility data resulting from nine listings comparing furosemide and vasopressin have variable results, according to micromedex and lexicomp 8,9.
1013 1349 1573 1022 1594 79 753 207 138 577 1599 11 745 1556 638 819 1083 1213 439 768 451 1370 1356 441 240 186 624 478 1031 248 618 1479 682 1436 1282 1349 137 1090 568 1409